Identifying large sets of unrelated individuals and unrelated markers
نویسندگان
چکیده
منابع مشابه
Mutational load analysis of unrelated individuals
Evolutionary genetic models predict that the cumulative effect of rare deleterious mutations across the genome-known as mutational load burden-increases the susceptibility to complex disease. To test the mutational load burden hypothesis, we adopted a two-tiered approach: assessing the impact of whole-exome minor allele load burden and then conducting individual-gene screening. For our primary ...
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Knowledge of haplotype phase is valuable for many analysis methods in the study of disease, population, and evolutionary genetics. Considerable research effort has been devoted to the development of statistical and computational methods that infer haplotype phase from genotype data. Although a substantial number of such methods have been developed, they have focused principally on inference fro...
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ژورنال
عنوان ژورنال: Source Code for Biology and Medicine
سال: 2014
ISSN: 1751-0473
DOI: 10.1186/1751-0473-9-6